PDE-5 inhibitors (e.g. Viagra, Cialis)
PDE-5 inhibitors are a group of drugs that are used to improve the ability to achieve an erection in men. Today, they are among the most important treatment options for erectile dysfunction (erectile dysfunction).
How do PDE-5 inhibitors work?
PDE-5 inhibitors block an enzyme in the body called phosphodiesterase type 5 ( PDE-5 for short). This enzyme normally breaks down a messenger substance(cGMP) that is responsible for relaxing the vascular muscles in the penis.
When PDE-5 is inhibited, more cGMP is retained. This allows the blood vessels to dilate better, the blood flows more easily into thecavernous bodies of the penis(corpora cavernosa) – and an erection is made possible or improved.
Important to know:
PDE-5 inhibitors only work with sexual stimulation. No erection occurs without appropriate stimulation.
Known active ingredients and trade names:
- Sildenafil (trade name: Viagra®)
- Tadalafil (trade name: Cialis®)
- Vardenafil (trade name: Levitra®)
- Avanafil (trade name: Spedra®)
Areas of application:
- Treatment of erectile dysfunction
- In low doses occasionally also for pulmonary hypertension (high lung pressure)
Possible side effects:
- Headache
- Reddening of the face
- Digestive problems
- Stuffy nose
- Rarely: Visual disturbances or cardiovascular problems
It is therefore important to consult a doctor before taking them, especially if you have an existing cardiovascular condition.
This content is for general information purposes only and does not constitute medical advice, diagnosis or treatment recommendations. It is in no way a substitute for a professional examination or treatment by a licensed physician. If you have any health complaints or uncertainties, please always consult a medical professional – especially if you have any questions about intimate surgery or sexual health.
